Appendix 1—table 1. Features of mitochondrial membranes.

Cell volumes are from Lynch and Marinov (2015), in some cases supplemented with additional references from the literature. $V$: cell volume (in μm³); $S{A}_C$: cellular surface area (in μm²); $S{A}_{MI}$: inner mitochondrial membrane surface area (in μm²); $S{A}_{MI+MO}$: inner+outer mitochondrial membrane surface area (in μm²); $MI/MO$ ratio between inner and outer mitochondrial membrane surface area

Species	$V$	$S{A}_C$	$S{A}_{MI}$	$S{A}_{MI+MO}$	$MI/MO$	References
Unicellular eukaryotes
Exophiala dermatitidis	43.80	50.95	73.98			Biswas et al. (2003)
Candida albicans	35.36	96.10	37.37			Tanaka et al. (1985); Klis et al. (2014)
Saccharomyces cerevisiae	69.07	61.42	15.83			Uchida et al. (2011)
Tetrahymena pyriformis	16666.00	3014.05	12987.60	83968.50	5.200	Gleason et al. (1975); Poole (1983)
Trichoderma viride	126.70	122.01	139.40			Rosen et al. (1974)
Mammals
Cat, gracilis muscle					2.323	Schwerzmann et al. (1989)
Hamster, intestinal enterocyte	1890.00	5772.00	2668.00	9351.00	3.256	Buschmann and Manke (1981a, 1981b)
Human HeLa cells	2798.67	1178.00	1424.74
Mouse heart					7.020	Kistler and Weber (1975)
Mouse liver					3.540	Kistler and Weber (1975)
Mouse lymphocyte	50.69	88.27	20.43			Al-Hamdani et al. (1979); Mayhew et al. (1979)
Mouse immunoblast	392.98	282.94	143.52			Al-Hamdani et al. (1979)
Mouse pancreas	1434.00	973.00	779.00			Dean (1973)
Pig pancreas cell	1060.00	581.90	460.50	2698.50	4.860	Bolender (1974)
Rat Leydig cell, testes	1210.00	1517.00	1641.00	4561.00	1.779	Mori and Christensen (1980)
Rat liver cell	5100.00	1680.00	7651.65	42615.56	4.718	Weibel et al. (1969); Jakovcic et al. (1978)
Rat heart					12.760	Reith et al. (1973)
Rat L-8 skeletal muscle cell					4.670	Reith et al. (1973)
Land plants and algae
Arabidopsis thaliana, cotyledon	5237.75		1307.00
Chlamydomonas reinhardtii	128.38	129.60	66.82			Calvayrac et al. (1974); Hayashi and Ueda (1989)
Chlorella fusca	102.00	111.40	48.40			Atkinson et al. (1974); Forde et al. (1976)
Dunaliella salina	590.80	322.50	87.40			Maeda and Thompson (1986)
Medicago sativa, meristem	166.90	221.50	16.00			Zhu et al. (1991)
Ochromonas danica					2.450	Smith-Johannsen and Gibbs, 1972
Ostreococcus tauri	0.91	8.30	0.70			Henderson et al. (2007)
Polytoma papillatum	862.54	471.43	778.64			Gaffal et al. (1982)
Rhus toxicodendron	1222.00			1288.50	2.545	Vassilyev (2000)