. 2017 Mar 16;6:e20437. doi: 10.7554/eLife.20437

Appendix 1—table 2. Estimated abundance of ATP synthase complexes in species with quantitative proteomics data.

ATP synthase surface area assumed to be maximum associated with the inner ring, 6.4 × 10⁻⁵m² for bacteria, 1.1 × 10⁻⁴ for eukaryotes. $V$ : cell volume (in μm³); $S A_{C}$ : cellular surface area (in μm²); $N_{P C, r a w}$ : raw protein complex copy number estimates; $N_{P C, c o r r}$ : corrected protein complex copy number estimates; $c_{R}$ : correction factor; $P D$ : packing density (copies/μm²); $f_{S A}$ : fraction of $S A$ : cell division time (hours); $C_{G}$ , $C_{M}$ , $C_{T}$ : costs of building a cell per in 10⁹ ATP equivalents; $C_{G}$ : growth; $C_{M}$ : maintenance (per hours); $C_{T}$ : total; $R_{m a x}$ and $R_{r e d}$ : maximum (all ATP equivalents) and reduced (without ATP equivalents expended in the form of NADH/NADPH/FADH₂) required rate of ATP synthesis (per complex per second) to satisfy lifetime energy requirements.

			F₀F ₁ copies per cell
Species	$V$	$S A_{C}$	$N_{P C, r a w}$	$N_{P C, c o r r}$	$c_{R}$	$P D$	$f_{S A}$	$t$	$C_{G}$	$C_{M}$	$C_{T}$	$R_{m a x}$	$R_{r e d}$	References
Prokaryotes
Bacillus subtilis	1.407	10.69	2435	1602	0.66	150	0.010	1.16	92.51	1.16	93.85	14062	2109	Jeong et al. (1990); Weart et al. (2007); Sharpe et al. (1998)
Escherichia coli	0.983	10.85	1056	3018	2.86	278	0.018	0.99	15.65	0.21	15.86	1475	221	Young (2006); Milo and Phillips, 2016
Leptospira interrogans	0.220	5.72	1187	1344	NA	235	0.015							Beck et al. (2009)
Mycoplasma pneumoniae	0.033	1.32	117	131	1.12	99	0.006	63.74	0.92	0.05	3.87	129	19	Zucker-Franklin et al. (1996a), 1996b
Staphylococcus aureus	0.288	4.00	447	NA	NA	112	0.007							Kehle and Herzog (1989)
Fungi
Saccharomyces cerevisiae (hap)	37.940	64.42	15659	29126	1.86	452	0.050	2.50	2468.20	18.79	2515.15	9598	1440
Schizosaccharomyces pombe	118.000	116.38	65363	70129	1.07	603	0.066	4.31	2347.80	8.70	2385.29	2193	329
Mammals
Homo sapiens , HeLa cell	2798.668	1178.00	1284376	737270	0.57	626	0.068							Borle (1969a, 1969b)
Mus musculus , fibroblast NIH3T3	1765.000	2100.00	1255254	NA	NA	598	0.066							Schwanhäusser et al. (2011)