Table 3.
NNH vs placebo for oral second-generation antipsychotics in adults
| Antipsychotics | NNH for weight gain ≥7%
|
NNH for somnolence adverse events
|
NNH for akathisia adverse events
|
|||
|---|---|---|---|---|---|---|
| Schizophrenia | Adjunctive for MDD | Schizophrenia | Adjunctive for MDD | Schizophrenia | Adjunctive for MDD | |
| Brexpiprazole | 17 | 52 | 50 | 34 | 112 | 15 |
| Aripiprazole | 21 | 22 | 20* | 50 | 25 | 5 |
| Cariprazine (to 6 mg/day) | 34 | 100 | 15 | |||
| Risperidone | 18* | 13 | 15 | |||
| Olanzapine | 6* | 3 | 7* | 11 | 25 | 167 |
| Quetiapine IR | 6 | 10* | ND | |||
| Quetiapine XR | 22 | 29 | 7 | 4 | 188 | 91 |
| Ziprasidone | 16 | 15 | 100 | |||
| Paliperidone | 35 | 42 | 38 | |||
| Iloperidone | 10 | 16 | ND | |||
| Asenapine | 35 | 17 | 34 | |||
| Lurasidone | 67 | 11 | 10 | |||
Notes: Adapted from Citrome L. The ABCs of dopamine receptor partial agonists-aripiprazole, brexpiprazole, and cariprazine: the 15-min challenge to sort these agents out. Int J Clin Pract. 2015;69(11):1211–1220, with permission from John Wiley and Sons, copyright 2015.27 ND, no difference or rate with medication is lower than rate with placebo.
*
Pooled schizophrenia and bipolar mania.
Abbreviations: NNH, number needed to harm; MDD, major depressive disorder; XR, extended release; IR, immediate release.