Table 2.

Specific proteins that interact with Rev

Possible interactor	Function
B23	Co-localizes with Rev in the nucleoli, helps Rev to maintain its presence in this location
P32	Overcome an import post-translational block of Rev
Nucleosome assembly protein	Nuclear import of Rev
Human I-mfa domain containing protein	Regulate Rev nuclear import
Poly(A) binding protein 1	Rev-related translation
Human Rev interacting protein	Promotes the release of incompletely spliced mRNA from the perinuclear region
Matrix-associated RNA binding protein	Stabilizes Rev–RRE interaction, a component of the nuclear pore proteome, frees mRNA from INS-mediated retention

Notes: This table lists the various cellular proteins that interact with the HIV-1 Rev protein and the resulting effect of this interaction. Adapted from Kula A, Marcello A. Dynamic post-transcriptional regulation of HIV-1 gene expression. Biology. 2012;1:116–133.35

Abbreviations: RRE, Rev response element; INS, instability.