Table 4.
Clusters within regions of interest (ROIs) showing age and slow wave activity (SWA) associations with regional cerebral metabolic rate of glucose uptake (rCMRglu)
| Predictor | ROI | Peak MNI coordinates (x,y,z) | Max cluster size | R2D | t | Z | df | P |
|---|---|---|---|---|---|---|---|---|
| Age | DLPFC | 30, 8, 60 | 849 | 0.17 | 3.67 | 3.43 | 1, 50 | 0.06 |
| OFC | −34, 18, −14 | 390 | 0.12 | 2.68 | 2.58 | 1, 50 | 0.23 | |
| aSWA | DLPFC | 32, 10, 58 | 37 | 0.07 | 1.93 | 1.89 | 1, 50 | 0.91 |
| OFC | – | – | – | – | – | – | – | |
| rSWA | DLPFC | −34, 14, 34 | 990 | 0.17 | 4.56 | 4.15 | 1, 50 | 0.03† |
| OFC | −38, 42, −8 | 152 | 0.10 | 2.58 | 2.49 | 1, 50 | 0.54 | |
| Age 9 aSWA | DLPFC | −32, 26, 26 | 439 | 0.03 | 3.83 | 3.56 | 1, 48 | 0.27 |
| OFC | −32, 32, −10 | 555 | 0.03 | 3.54 | 3.32 | 1, 48 | 0.11 | |
| Age 9 rSWA | DLPFC | −28, 50, 8 | 125 | 0.09 | 2.09 | 2.04 | 1, 48 | 0.74 |
| OFC | −34, 32, −8 | 185 | 0.11 | 2.78 | 2.66 | 1, 48 | 0.47 |
aSWA, absolute slow wave activity; rSWA, relative slow wave activity; DLPFC, dorsolateral prefrontal cortex; OFC, orbitofrontal cortex.
Significant relationships are highlighted in bold font.
†
significance after controlling for grey matter volume; –: no suprathreshold clusters. MNI coordinates and t-values represent peak-level statistics. Cluster size and P-values represent Alpha Sim-corrected cluster-level statistics.