Table 1.

Histone modifications involved in aging and apoptotic processes in yeast. The implications listed are referring to the respective histone modifications. The listed writers and erasers may have impact on other histone modifications not related to cell death as well and the modifiers may have targets other than the histones, which may implicate them in other cell death pathways.

Histone	Modification	Writer	Eraser	Implication	Reference
H2A	S122 phosphorylation			H202	48
H2A	S129 phosphorylation	Mec1, Tel1	PPH3	H202	152,153
H2B	S10 phosphorylation	Ste20		H202	30
H2B	K11 acetylation		Hos3	H202	31
H2B	K123 ubiquitination	Rad6/Bre1	Ubp10, Ubp8	CLS, RLS, H202	32,35,49,50,53,72,73
H3	K4 methylation	Set1/COMPASS	Jhd2	CLS, RLS, H202	33,35,57,121,154,155
H3	K36 methylation	Set2	Jhd1	RLS	124,143,156
H3	K79 methylation	Dot1		RLS	33,129
H3	T45 phosphorylation	AKT1, 2		H202	47,157
H3	K9 acetylation	Gcn5		CLS	161,164
H3	K14 acetylation	Sas3	Hos3	CLS	161,164
H3	K18 acetylation	Gcn5		CLS	161,164
H3	K56 acetylation	Asf1, Rtt109	Hst3, Hst4	RLS	91,152,153,158
H4	K16 acetylation	Sas2	Sir2	RLS	87,159,160