Figure 1. FIGURE 1: Phenotypes occurring in the yeast replicative lifespan.

Observations collected from primary literature as discussed herein and as associated to a relevant hallmark of aging (symbol in legend). Cited references are often not the first to observe the phenotype but are selected based on the earliest most precise report of the timing within the RLS (i.e. while 23,24 described aged cells to be larger than young, 25 clearly observed this increase in size for a specific age, namely from the beginning on, when 100% of the population was still viable). Percentage of viability, at which age-related phenotype occurs in the population, was either directly taken from the primary literature source, or inferred based on the age of the yeast used in the publication, its average lifespan (if provided), or the average lifespan estimated from a compiled lifespan curve.