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. 2016 Dec 30;8(6):10238–10254. doi: 10.18632/oncotarget.14380

Figure 2. Lytic replication in LCLs infected with multiple EBV strains.

Figure 2

A. Representative BZLF1 and gp350 immunofluorescence stains performed on one set of LCLs generated with the same blood sample. B. The percentage of BZLF1- or gp350-positive cells in LCLs generated by the infection of 7 independent blood samples with 6 viruses. The 2 dot plots give the percentage of positive cells 4 weeks after infection. C. Representative BZLF1 and gp350-specific immunoblots performed on one set of LCLs generated with the same blood sample. Actin served as loading control. The 220kDa signals observed in the gp350-specific immunoblots are generated by a gp350 splice variant. The dot plot summarizes the BZLF1 protein levels observed after infection of five individual blood samples with the virus panel 1 month post-infection. The results are given relative to signals obtained with M81. The p-values shown in (B) give the results of global test analyses by using global mixed linear model analyses with random effect. In (C) we applied log-transformation of fold-changes for the analysis of normalized data without Bonferroni correction. Error bars represent the mean with s.d.