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. 2016 Dec 31;8(6):10312–10323. doi: 10.18632/oncotarget.14400

Figure 4. Analysis of TCGA data to identify frequency of DNA repair mutations.

Figure 4

a. Analysis of 22 DNA repair related genes involved in NHEJ. a) 9064 tumor samples were examined across 24 cancer types, with 15.9% of tumors exhibiting at least one alteration among the 22 genes. ATM was the most highly mutated, with 19.6% of tumors exhibiting some type of ATM alteration. b. Prevalence of NHEJ pathway alterations are listed by cancer type. The most commonly mutated gene within the pathway, for each cancer type, is listed below the corresponding cancer type. ATM was the most commonly mutated gene in fifteen of the 24 cancer types (62.5%). Red text identifies cancers for which radiation is used as standard of care as either definitive or adjuvant treatment. Adrenocortical carcinoma [ACC], Bladder Urothelial Carcinoma [BLCA], Glioblastoma multiforme [GBM], Head and Neck squamous cell carcinoma [HNSC], Kidney Chromophobe [KICH], Kidney renal clear cell carcinoma [KIRC], Kidney renal papillary cell carcinoma [KIRP], Brain Lower Grade Glioma [LGG], Lung adenocarcinoma [LUAD], Lung squamous cell carcinoma [LUSC], Pheochromocytoma and Paraganglioma [PCPG], Skin Cutaneous Melanoma [SKCM], Uterine Corpus Endometrial Carcinoma [UCEC], Uterine Carcinosarcoma [UCS].