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. 2016 Dec 31;8(6):10324–10347. doi: 10.18632/oncotarget.14401

Figure 3. Src controls the expression of AR-dependent genes in a DHT-independent manner.

Figure 3

A. Measurement by qRT-PCR of TMPRSS2, KLK3(PSA) and AR in LNCaP or in LNCaP[Src527F] treated for 24h with vehicle (1% DMSO), Dasatinib (100 nM) or DHT (1 nM). B. ChIP assays on PC cells treated with vehicle or 10 nM DHT for 16h, using primers specific for the PSA enhancer (+) or a non-ARE PSA site (-), and AR-specific Ab vs. control IgG, as described in Materials and Methods. Error bars, mean +/- SEM from 3 independent experiments. N.S., not significant.