Figure 4. Genes regulated by Src in the presence or absence of DHT.

Transcriptome comparisons between LNCaP + DHT vs. LNCaP[Src^527F] cells A., or between DHT-treated LNCaP vs. LNCaP[Src^527F] cells C., with a differential expression threshold of log₂^≥3. B. The 10 most differentially expressed genes shared by DHT treatment or Src^527F expression in LNCaP cells (red: upregulated; green: downregulated). ARGDB: androgen responsive gene database (http://argdb.fudan.edu.cn/). D. Examples of genes whose DHT-induced expression (“Up”- or “Down”-regulation; ↔, no change) was altered in an opposite manner by Src. Note that all these genes were identified in the ARDGB or in GEO GSE7868 study of Wang et al. [75], which identified DHT-regulated genes in LNCaP cells.