Table 1. Relationship between the expression of Notch1 or Numb and clinical and clinicopathological characteristics in 125 cases with surgically resected small cell lung cancer.
| Characteristics | Notch1 expression | Numb expression | ||||
|---|---|---|---|---|---|---|
| No. of Patients | No. of Patients | |||||
| Low | High | P | Low | High | P | |
| Age (years) | ||||||
| <65 | 28 | 10 | 1.000 | 25 | 13 | 0.032 |
| ≧65 | 64 | 23 | 38 | 49 | ||
| Sex | ||||||
| Male | 70 | 25 | 1.000 | 41 | 54 | 0.006 |
| Female | 22 | 8 | 22 | 8 | ||
| Smoking | ||||||
| Smoker | 80 | 28 | 0.457 | 53 | 55 | 0.323 |
| Nonsmoker | 6 | 4 | 7 | 3 | ||
| Unknown | 6 | 1 | 3 | 4 | ||
| Smoking (pack-years) | ||||||
| ≧20 | 76 | 28 | 1.000 | 50 | 54 | 0.154 |
| <20 | 10 | 4 | 10 | 4 | ||
| Unknown | 6 | 1 | 3 | 4 | ||
| ECOG PSa | ||||||
| 0 | 59 | 29 | 0.004 | 46 | 42 | 0.836 |
| 1 | 28 | 2 | 15 | 15 | ||
| Unknown | 5 | 2 | 2 | 5 | ||
| Histlogy | ||||||
| SCLCb | 6721 | 0.376 | 51 | 37 | 0.011 | |
| Combined SCLC | 25 | 12 | 12 | 25 | ||
| pTc | ||||||
| T1 | 54 | 16 | 0.414 | 32 | 38 | 0.281 |
| T2-4 | 38 | 17 | 31 | 24 | ||
| pNd | ||||||
| N0 | 60 | 21 | 0.833 | 42 | 39 | 0.706 |
| N1-3 | 31 | 12 | 20 | 23 | ||
| pStagee | ||||||
| I | 54 | 20 | 1.000 | 37 | 37 | 1.000 |
| II-IV | 38 | 13 | 26 | 25 | ||
| Adjuvant chemotherapy | ||||||
| Yes | 55 | 21 | 0.837 | 38 | 38 | 1.000 |
| No | 35 | 12 | 23 | 24 | ||
| Unknown | 2 | 0 | 2 | 0 | Eastern | |
a Eastern Cooperative Oncology Group performance status.
b Small cell lung cancer.
c Pathological tumor classification.
d Pathological lymph node status.
e Pathological disease stage.