Figure 4. Domain-lacking reduced protein expression level of key nodes of MUC4/Y-mediated signal path in the majority.

Representative signaling pathways mediated by MUC4/Y were described as earlier research [16] (Additional File 4, Supplementary Figure S1). WB validation results of the expression changes of the key nodes in the signal path and measurement of optical density value by Image J software. The expression quantity in controls is defined as 1.0, so under the line of “1.0” represents mean expression quantity of experimental groups below that of control group, and under the line of “0.5” represents mean expression quantity of experimental group less than 50% expression of control group.