Table 2. Associations between immunity gene SNPs and NHL risk.
| Gene | SNP | Minor allele | Alternative allele | Control (%) | Overall NHL | B-Cell Lymphomas | DLBCL | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AFF (%) | ORper-minor-allele (95% CI)≠ | PCA_BH | Plogistic_BH | AFF (%)* | ORper-minor-allele (95% CI)≠ | PCA_BH | Plogistic_BH | AFF (%)* | ORper-minor-allele (95% CI)≠ | PCA_BH | Plogistic_BH | |||||
| IL-10 | rs1518111 | G | A | 12/46/36 | 9/53/34 | 1.16 (0.83-1.60) | 0.776 | 0.492 | 8/51/37 | 1.08 (0.77-1.53) | 0.710 | 0.677 | 10/48/37 | 1.11 (0.75-1.67) | 0.667 | 0.598 |
| IL-10 | rs1800893 | T | C | 1/30/62 | 2/53/40 | 2.64 (1.75-3.98) | <0.0001 | <0.0001 | 1/55/40 | 2.75 (1.79-4.23) | <0.0001 | <0.0001 | 2/55/37 | 3.03 (1.83-5.01) | <0.0001 | <0.0001 |
| IL-10 | rs3021094 | G | T | 17/49/24 | 14/53/24 | 0.86 (0.62-1.20) | 0.648 | 0.492 | 15/55/20 | 0.96 (0.68-1.36) | 0.860 | 0.861 | 17/60/18 | 1.12 (0.74-1.68) | 0.449 | 0.598 |
| IL-1RN | rs4251961 | C | T | 1/17/74 | 4/27/64 | 2.67 (1.72-4.16) | 0.001 | <0.0001 | 4/27/65 | 2.75 (1.73-4.36) | 0.003 | 0.003 | 4/31/60 | 3.39 (1.99-5.79) | <0.0001 | <0.0001 |
| TNF-α | rs1041981 | T | G | 17/49/25 | 19/55/18 | 1.34 (0.96-1.87) | 0.211 | 0.146 | 21/55/16 | 1.45 (1.02-2.05) | 0.087 | 0.087 | 25/57/12 | 1.73 (1.14-2.61) | 0.021 | 0.022 |
| rs1800629 | A | G | 0/14/76 | 1/12/79 | 0.89 (0.49-1.59) | 0.659 | 0.785 | 1/13/78 | 1.02 (0.56-1.85) | 0.861 | 0.957 | 1/10/83 | 0.79 (0.38-1.67) | 0.449 | 0.598 | |
| rs1800630 | A | C | 4/24/64 | 1/46/49 | 1.80 (1.24-2.63) | 0.007 | 0.006 | 1/44/51 | 1.76 (1.19-2.61) | 0.028 | 0.015 | 0/45/51 | 1.88 (1.17-3.03) | 0.119 | 0.022 | |
| rs2229094 | G | A | 2/25/51 | 2/37/48 | 1.55 (1.02-2.37) | 0.132 | 0.089 | 2/37/50 | 1.52 (0.98-2.36) | 0.198 | 0.113 | 1/43/47 | 1.83 (1.09-3.08) | 0.129 | 0.042 | |
* Proportion of samples with the genotypes (rare homozygosity/ heterozygosity /common homozygosity) in the given group;
≠ Calculated from multiple logistic regression model adjusted for sex, age, education, family history of NHL, smoking, environmental exposures, and body mass index (BMI).
SNP, single nucleotide polymorphism; AFF, number of cases with rare homozygous, heterozygous and common homozygous genotypes; ORper-minor-allele, per-minor-allele odds ratio; 95% CI, 95% confidence interval; PCA_BH, p value of Cochran-Armitage trend test (univariate analysis) corrected for multiple testing using Benjamini and Hochberg (BH) approach; Plogisticlogistic_BH, p value of multiple logistic regression model corrected for multiple testing using BH approach; DLBCL, diffuse large B-cell lymphomas; NHL, non-Hodgkin lymphoma.