Table 3. The trends of RET/PTC rearrangements prevalence of classical PTCs from individual institutions.
| Country | City (State) | Institution (Reference) |
Prevalence of RET/PTC rearrangements in classical PTCs | ||||
|---|---|---|---|---|---|---|---|
| Period 1 | Period 2 | Period 3 | Period 4 | P | |||
| US | San Francisco (CA) | UCSF [13] | 1991-1995 10/74 (13.5%) Nested PCR |
1996-2000 19/103 (18.4%) Nested PCR |
2001-2005 2/51 (3.9%) Nested PCR |
0.047 | |
| US | Pittsburgh (PA) | Univ. of Pittsburgh [14] | 1974-1985 6/52 (11.5%) DCI FISH |
1990-1992 1/18 (5.6%) DCI FISH |
2000 2/23 (8.7%) DCI FISH |
2009 1/65 (1.5%) DCI FISH |
NS |
| Japan | Yamanashi | Univ. of Yamanashi [22, 23] | 2001-2006 4/14 (28.6%) Nested PCR |
2011-2014 1/59 (1.7%) Nested PCR |
<0.001 | ||
| Ireland | Dublin | St. James's Hospital [20] | 1982-1992 2/3 (66.7%) RT-PCR |
1993-2002 4/15 (26.7%) RT-PCR |
NS | ||
Abbreviations: DCI FISH, dual colour interphase fluorescent in situ hybridization; RT-PCR, reverse transcription PCR