Table 6. Modifications of demographic and clinicopathological characteristics of PTCs over time from individual institutions.
| Country | Institution (Reference) |
Period | Patients’ age (years) | p | Male (%) |
p | Tumor size (%) |
p | FVPTC (%) | p | ETE (%) |
p | LNM (%) |
p |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| US | University of Pittsburgh[14] | 1974-1985 1990-1992 2000 2009 |
Median, 37 Median, 37 Median, 50 Median, 53 |
<0.001 | 27.6 27.1 13.2 24.5 |
NS | ≤1cm, 42.0 ≤1cm, 44.1 ≤1cm, 41.5 ≤1cm, 51.3 |
NS | 10.2 3.4 13.2 25.2 |
<0.001 | 40.2 27.1 26.9 20.9 |
0.005 | 26.8 28.8 20.8 18.3 |
<0.001 |
| Italy | University of Padua[28, 29] | 2005-2007 2008-2009 |
Mean, 43.6* Mean, 49.0 |
0.003 | 28.9 22.7 |
NS | ND ≤1cm, 24.9 |
NA | 3.6 3.5 |
NS | ND 45.4 |
NA | 51.8 38.3 |
0.049 |
| Italy | Endocrine units of Pisa/Perugia/ Milan [11] | 1996-2000 2001-2005 2006-2010 |
Mean, 40.9 Mean, 44.0 Mean, 47.6 |
0.014 | 32.0 25.0 32.7 |
NS | <2cm, 43.3 <2cm, 59.4 <2cm, 61.0 |
0.01 | 12.3 18.4 15.3 |
NS | T3/T4, 45 T3/T4, 39 T3/T4, 35 |
0.005 | 50.7 48.1 51.9 |
NS |
| Poland | Holycross Cancer Center [21] | 2000-2004 2005-2009 2010-2013 |
Median, 50 Median, 53 Median, 53 |
NS | 11.3 11.6 13.1 |
NS | ≤1cm, 50.8 ≤1cm, 63.1 ≤1cm, 64.9 |
0.003 | 11.3 12.9 15.0 |
NS | 22.5 25.3 24.9 |
NS | 12.4 12.9 13.7 |
NS |
| Korea | Samsung Medical Centre[27, 30] | 2008 2010-2011 |
Mean, 47.0 Mean, 48.0 |
NS | 18.5 16.9 |
NS | ≤1cm, 55.6 ≤1cm, 80.5 |
<0.001 | 2.9 ND |
NA | 62.2 53.5 |
NS | 48.1 36.5 |
0.043 |
Abbreviations: FVPTC, follicular variant papillary thyroid carcinoma; ETE, extrathyroidal extension; LNM, Lymph node metastasis; NS, not significant; NA, not available; ND, not described
* Estimated the sample mean and standard deviation as described by Hozo et al. [16]