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. 2016 Oct 25;8(6):10662–10674. doi: 10.18632/oncotarget.12891

Figure 2. Mechanisms of FoxO1 in the regulation of slow skeletal muscle fiber gene expression.

Figure 2

FoxO1 downregulates calcineurin (CaN), CaMK and MEF2C expression, leading to a decrease of MEF2C that can increase the transcriptional activation of slow fiber genes, to inhibit slow fiber genes expression. In addition, PGC1α induces fiber-type switching from glycolytic toward oxidative fibers. FoxO1 may interact with PGC1α to inhibit certain functions of PGC1α, inhibiting expression of slow fiber gene.