Table 2. The characteristics of tumors developed by each risk group.

	VHR Group	HR Group	IR Group	p-value
N° of BC (255 patients)	45 (40)	160 (10)	50 (6)	< 0.001
Mean age (SD)	44 (11)	49 (11)	50 (10)	0.007
HER2 status (%) (143 patients)
Positive	1 (4)	8 (9)	4 (15)	0.545
Negative	24 (96)	80 (91)	26 (87)
Hormone Receptor Status (%) (174 patients)
Positive	21 (60)	88 (83)	25 (76)	0.024
Negative	14 (40)	18 (17)	8 (24)
Age at diagnosis (%) (248 patients)
≤ 35 years	9 (20)	16 (10)	0	0.002
> 35 years	35 (80)	139 (90)	49 (100)
Invasive Carcinoma (%) (225 patients)
Yes	34 (85)	108 (78)	33 (72)	0.338
No	6 (15)	31 (22)	13 (28)
Multiple Carcinoma in the lifetime (%) (247 patients)
Yes	10 (23)	11 (7)	4 (8)	0.017
No	34 (77)	144 (93)	44 (92)

Statistical test: one-way ANOVA for age; for categorical variables chi2 test or Fischer's exact test, when appropriate.

Abbreviations: VHR = Very High Risk, HR = High Risk, IR = Intermediate Risk, BC = Breast Cancer, SD = Standard Deviation.