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. 2016 Dec 20;8(6):9267–9279. doi: 10.18632/oncotarget.14035

Figure 2. ER stress decreased Sirt1 and increased apoptosis in the brown adipose tissue.

Figure 2

(A) Relative mRNA levels of Sirt1, UCP1, PRDM16 and Cidea in iBAT of mice fed on HFD injected with or without tunicamycin (TM, 1 μg/g) (n = 6); (B) ATP level in iBAT of mice fed on HFD injected with or without TM (n = 6); (C) Relative mRNA levels of GRP78, Chop and ATF4 in iBAT of mice fed on HFD injected with or without TM (n = 6); (D) Relative mRNA levels of Caspase3, Bcl2, Bax and Caspase12 in iBAT of mice fed on HFD injected with or without TM (n = 6); (E) Relative mRNA levels of GRP78, Chop, ATF4, Bcl2, Bax and Caspase3 in iBAT of mice fed on HFD injected with or without Tg (n = 6). Values are means ± SEM, *p < 0.05 compared with the control group.