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. 2016 Dec 20;8(6):9267–9279. doi: 10.18632/oncotarget.14035

Figure 8. Sirt1 alleviated ER stress-induced cold intolerance in mice.

Figure 8

(A) Relative mRNA level of Sirt1, UCP1 and PRDM16 in the brown adipose tissue of mice kept under 10°C for 2 days, and injected with TM or not in the mice pre-treated with pAd-Sirt1 (n = 6); (B) Temperature of mice kept under 10°C for 2 days, and injected with TM or not in the mice pre-treated with pAd-Sirt1 (n = 6); (C) ATP level of mice kept under 10°C for 2 days, and injected with TM or not in the mice pre-treated with pAd-Sirt1 (n = 6); (D) Protein levels of Chop, GRP78, ATF4, and Smad3 of mice kept under 10°C for 2 days, and injected with TM or not in the mice pre-treated with pAd-Sirt1 (n = 6); (E) Protein levels of Caspase12, Bax, Bcl-2 and Caspase3 of mice kept under 10°C for 2 days, and injected with TM or not in the mice pre-treated with pAd-Sirt1 (n = 6). pAd-Sirt1: over-expression recombinant adenovirus vector of Sirt1. Values are means ± SEM. *p < 0.05, #p < 0.05 compared with the control group.