Figure 2. Alterations in central Wnt and EMT genes in prostate cancer compared with normal samples (balanced for stroma), high Gleason compared with low Gleason prostate cancer, and high stroma content compared with low stroma content (unbalanced) tissue samples.

The x-axis displays log10(p-value) fold change, multiplied by −1 for upregulated genes, and 1 for downregulated genes. P-values for prostate cancer vs. normal prostate tissue are balanced for stroma content; unbalanced p-values are available in Supplementary Table 2. A. The central canonical genes show a pattern of no further activation in cancer or high Gleason cancer, but show a confounding stroma effect, especially of the genes of the destruction complex. B. The central non-canonical genes generally show an upregulation of Wnt5/Fzd2 genes in high Gleason cancer. C. The central epithelial-mesenchymal transition (EMT) positive genes indicate ongoing EMT, especially in high Gleason cancer. D. The central EMT negative genes.