Figure 4. The NCWP-EMT gene expression signature.

A. Two component PCA plot reveals a group of 15 of 48 genes, mainly connected to Wnt5a/Fzd2 non-canonical Wnt pathway, epithelial-mesenchymal transition (EMT), and inhibitors of the canonical Wnt pathway, collectively termed NCWP-EMT (CDH2, CDH3, CDH11, FYN, FZD2, LEF1, MMP9, NKD2, PLCB2, SFRP1, SFRP2, SFRP4, VIM, TCF4 WNT5A). B. The Pearson correlation of co-expression of the genes in the NCWP-EMT signature is as good or better compared with other recognized genes expression signatures in prostate cancer. Random marks 200 randomly selected genes for validation. C-G. The NCWP-EMT signature confirmed in the validation cohorts, although there were some variations in the highlighted genes. High-resolution versions of the PCA plots including all gene names, and Pearson correlation of the validation cohorts are available in Supplementary Figure 1.