Table 2. Alterations in citrate and spermine metabolism.
| Metabolite concentration (mmol/kg wet weight) ex vivo and metabolites amount/ratios in vivo | p-valuesa | |||||
|---|---|---|---|---|---|---|
| Signature score | Low | Intermediate(Int) | High | Low vs. High | Int. vs High | Low vs. Int. |
| Median (IQR) | Median (IQR) | Median (IQR) | ||||
| Ex vivo (n=95) | (n=32) | (n=31) | (n=32) | |||
| Citrate | 7.31 (5.57-11.56) | 6.38 (4.56-11.58) | 3.55 (2.08-7.25) | 3.38·10-4* | 0.018* | 0.282 |
| Spermine | 1.55 (1.02-2.36) | 1.23 (0.67-2.27) | 0.75 (0.39-1.43) | 3.38·10-4* | 0.028* | 0.113 |
| In vivo (n=22) | (n=10) | (n=7) | (n=5) | |||
| Citrate/Creatine | 7.36 (5.81-8.79) | 4.45 (3.34-7.79) | 2.77 (1.48-3.00) | 0.0056* | 0.027* | 0.030* |
| Spermine/Creatine | 0.83 (0.44-1.04) | 0.50 (0.04-1.11) | 0.00 (0.00-0.02) | 0.0057* | 0.027* | 0.101 |
IQR – Interquartile range
* Indicates significance at p<0.05
a P-values from LMM adjusting for multiple samples per patient, and corrected for multiple testing by Benjamini and Hochberg procedure.