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. 2016 Dec 26;8(6):9783–9793. doi: 10.18632/oncotarget.14189

Figure 4. Down-regulation of FOXN3 activated beta-catenin/TCF signaling in colon cancer cells.

Figure 4

A. Over-expression of FOXN3 inhibited the activity of Topflash, an indicator for beta-catenin/TCF signaling, both at the basal level and upon the stimulation of LiCl. B. Knocking down the expression of FOXN3 up-regulated the expression of N-cadherin, Snail and c-Myc. C. ICG001, the inhibitor for beta-catenin/TCF signaling, abolished the advantage on the anchorage-independent growth induced by knocking down the expression of FOXN3. D. ICG001abolished the advantage on the migration of SW620 cells induced by knocking down the expression of FOXN3. E. ICG001abolished the advantage on the invasion of SW620 and SW480 cells induced by down-regulation of FOXN3.