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. 2016 Dec 26;8(6):9806–9822. doi: 10.18632/oncotarget.14190

Table 1. Characteristics of the studies included in the current meta-analysis.

Surname Year Cancer type Country Ethnicity Control Source Genotype method Case Control MAF HWE Score
II ID DD All II ID DD All
Lin [25] 2006 OSCC China Asian HB PCR-PAGE 59 103 50 212 43 100 58 201 0.54 0.993 7
Riemann [26] 2006 Colorectal cancer Germany Caucasian HB Pyro sequencing 54 58 27 139 118 141 48 307 0.39 0.586 9
Riemann [26] 2006 CLL Germany Caucasian HB Pyro sequencing 18 41 13 72 118 141 48 307 0.39 0.586 9
Riemann [26] 2006 RCC Germany Caucasian HB Pyro sequencing 47 76 17 140 118 141 48 307 0.39 0.586 9
Bu [48] 2007 Melanoma Sweden Caucasian HB PCR-RFLP 67 84 34 185 116 255 67 438 0.44 0.000 10
Riemann [83] 2007 Bladder cancer Germany Caucasian HB Pyro sequencing 88 124 30 242 118 141 48 307 0.39 0.586 10
Lehnerdt [27] 2008 HNSCC Germany Caucasian HB Pyro sequencing 132 179 53 364 118 141 48 307 0.39 0.586 8
He [82] 2009 HCC China Asian HB PCR-RFLP 83 84 35 202 97 183 124 404 0.53 0.070 9
He [89] 2009 HCC China Asian HB PCR-RFLP 55 65 30 150 70 136 94 300 0.54 0.130 8
Lo [24] 2009 Gastric cancer China Asian HB PCR 62 89 31 182 20 62 34 116 0.56 0.361 7
Zhang [81] 2009 Prostate cancer China Asian HB PCR-PAGE 46 57 14 117 44 68 31 143 0.45 0.624 8
Zhou [80] 2009 NPC China Asian HB PCR-PAGE 74 67 22 163 71 90 42 203 0.43 0.177 7
Tang [79] 2010 Bladder cancer China Asian HB PCR–PAGE 89 92 26 207 74 108 46 228 0.44 0.565 10
Zhou [78] 2010 Cervical cancer China Asian HB PCR–PAGE 108 105 20 233 135 166 64 365 0.40 0.297 9
Fan [77] 2011 Ovarian cancer China Asian HB PCR-CE 78 84 17 179 76 103 44 223 0.43 0.396 8
Lin [76] 2012 OSCC China Asian HB TaqMan 116 246 100 462 81 271 168 520 0.58 0.099 9
Song [92] 2012 Colorectal cancer China Asian HB PCR-RFLP 363 500 138 1001 297 522 186 1005 0.44 0.102 14
Tang [87] 2012 HCC China Asian HB PCR-RFLP 52 84 14 150 57 82 11 150 0.35 0.011 7
Ungerback [75] 2012 Colorectal cancer Sweden Caucasian HB TaqMan 114 187 43 344 256 270 96 622 0.37 0.079 8
Vangsted [74] 2012 Multiple myeloma Denmark Caucasian PB TaqMan 110 163 55 328 655 778 253 1686 0.38 0.303 7
Arisawa [73] 2013 Gastric cancer Japan Asian PB PCR-SSCP 172 239 68 479 342 435 103 880 0.36 0.046 11
Cheng [23] 2013 HCC China Asian HB TaqMan 42 64 29 135 81 271 168 520 0.58 0.099 7
Huang [72] 2013 Lung cancer China Asian PB TaqMan 372 459 225 1056 355 491 210 1056 0.43 0.090 10
Huang [72] 2013 Lung cancer China Asian PB TaqMan 169 230 104 503 189 289 145 623 0.46 0.092 10
Huo [71] 2013 Ovarian cancer China Asian HB Mass ARRAY 83 82 22 187 71 103 47 221 0.45 0.399 7
Kopp [70] 2013 Prostate cancer Denmark Caucasian PB RT-PCR 128 152 54 334 109 161 64 334 0.43 0.741 11
Li [69] 2013 Bladder cancer China Asian HB TaqMan 189 269 151 609 223 324 93 640 0.40 0.156 11
Liu [86] 2013 NPC China Asian PB TaqMan 116 135 49 300 86 143 71 300 0.48 0.443 12
Song [84] 2013 EC China Asian HB PCR-RFLP 42 52 6 100 56 39 5 100 0.25 0.588 6
Song [85] 2013 Cervical cancer China Asian HB PCR-RFLP 34 56 10 100 37 55 8 100 0.36 0.044 5
Umar [68] 2013 ESCC India Asian HB PCR 131 132 27 290 160 129 22 311 0.28 0.561 10
Gao [67] 2014 HCC China Asian PB TaqMan 68 102 40 210 171 160 79 410 0.39 0.000 12
Hua [66] 2014 Gastric cancer China Asian HB Mass ARRAY 92 182 127 401 120 230 83 433 0.46 0.144 9
Oltulu [65] 2014 Lung cancer Turkey Caucasian HB PCR-RFLP 35 44 16 95 46 47 6 99 0.30 0.194 7
Wang [64] 2014 Breast cancer China Asian HB PCR-RFLP 93 210 171 474 162 216 123 501 0.46 0.003 9
Zhang [63] 2014 HCC China Asian PB PCR 205 312 107 624 542 790 274 1606 0.42 0.631 10
Chen [62] 2015 Ovarian cancer China Asian HB Mass ARRAY 120 195 95 410 85 235 122 442 0.54 0.136 9
Cui [61] 2015 Prostate cancer China Asian HB PCR-RFLP 198 246 99 543 212 355 186 753 0.48 0.125 10
Han [60] 2015 Prostate cancer China Asian PB PCR-RFLP 63 339 534 936 38 331 567 936 0.78 0.230 12
Kopp [59] 2015 Colorectal cancer Denmark Caucasian PB KASP 320 449 146 915 679 787 253 1719 0.38 0.311 11
Li [58] 2015 Osteosarcoma China Asian HB PCR-RFLP 60 114 46 220 50 106 66 222 0.54 0.551 9
Liu [57] 2015 NPC China Asian HB TaqMan 236 331 117 684 274 438 195 907 0.46 0.420 9
Liu [57] 2015 NPC China Asian HB TaqMan 316 438 152 906 336 512 224 1072 0.45 0.262 9
Pallavi [56] 2015 Cervical cancer Iran Asian HB PCR-RFLP 98 116 26 240 73 104 113 290 0.57 0.000 9
Wang [55] 2015 Lung cancer China Asian HB PCR-RFLP 113 219 89 421 89 205 131 425 0.55 0.595 10
Wang [54] 2015 Thyroid carcinoma China Asian HB PCR-PAGE 106 186 60 352 171 209 79 459 0.40 0.273 11
Zhang [53] 2015 Lung cancer China Asian HB PCR-RFLP 434 252 32 718 352 290 76 718 0.31 0.162 9
Eskandari [52] 2016 Breast cancer Iran Asian HB AS-PCR 96 122 18 236 62 106 35 203 0.43 0.368 8
Lu [51] 2016 Ovarian cancer China Asian HB PCR-RFLP 115 351 221 687 95 339 253 687 0.61 0.271 10
Rybka [50] 2016 AML Poland Caucasian HB PCR 25 30 7 62 43 69 14 126 0.38 0.079 4

MAF, minor allele frequency; HWE, Hardy-Weinberg equilibrium; OSCC, oral squamous cell carcinoma; CLL, chronic lymphocytic leukemia; RCC, renal cell carcinoma; HNSCC, head and neck squamous cell carcinoma; HCC, hepatocellular carcinoma; NPC, nasopharyngeal carcinoma; ESCC, esophageal squamous cell carcinoma; EC, endometrial carcinoma; AML, acute myeloid leukemia; PB, population based; HB, hospital based; PCR-PAGE, polymerase chain reaction-polyacrylamide gel electrophoresis; PCR-RFLP, polymerase chain reaction-restriction fragment length polymorphism; PCR-CE, polymerase chain reaction-capillary electrophoresis; PCR-SSCP, polymerase chain reaction-single strand conformation polymorphism; KASP, kompetitive allele specific PCR; AS-PCR, allele-specific polymerase chain reaction.