Table 3. False-positive report probability values for associations between the NFKB1 -94ins/delATTG polymorphism and overall cancer risk.
| Variables | OR (95% CI) | P a | Power b | Prior Probability | ||||
|---|---|---|---|---|---|---|---|---|
| 0.25 | 0.1 | 0.01 | 0.001 | 0.0001 | ||||
| Homozygous (DD vs. II) | ||||||||
| All | 0.75 (0.64-0.87) | 2.45*10-4 | 1.000 | 0.001 | 0.002 | 0.024 | 0.197 | 0.710 |
| NPC | 0.66 (0.56-0.78) | 1.99*10-6 | 0.652 | 0.000 | 0.000 | 0.000 | 0.003 | 0.030 |
| Prostate | 0.59 (0.48-0.72) | 6.40*10-7 | 0.860 | 0.000 | 0.000 | 0.000 | 0.001 | 0.007 |
| Ovarian | 0.54 (0.40-0.73) | 6.62*10-6 | 0.612 | 0.000 | 0.000 | 0.001 | 0.011 | 0.098 |
| OSCC | 0.49 (0.33-0.72) | 3.26*10-4 | 0.388 | 0.003 | 0.008 | 0.077 | 0.457 | 0.894 |
| Asians | 0.67 (0.55-0.80) | 1.81*10-5 | 1.000 | 0.000 | 0.000 | 0.002 | 0.018 | 0.153 |
| Chinese | 0.68 (0.56-0.81) | 3.45*10-5 | 1.000 | 0.000 | 0.000 | 0.003 | 0.033 | 0.257 |
| HB | 0.70 (0.58-0.85) | 3.30*10-4 | 1.000 | 0.001 | 0.003 | 0.032 | 0.248 | 0.767 |
| QS ≤9 | 0.68 (0.53-0.86) | 1.63*10-3 | 1.000 | 0.005 | 0.014 | 0.139 | 0.620 | 0.942 |
| Heterozygous (ID vs. II) | ||||||||
| All | 0.91 (0.83-0.99) | 0.024 | 1.000 | 0.066 | 0.175 | 0.700 | 0.959 | 0.996 |
| Lung | 0.84 (0.74-0.96) | 7.74*10-3 | 1.000 | 0.023 | 0.065 | 0.434 | 0.885 | 0.987 |
| NPC | 0.85 (0.75-0.97) | 0.017 | 1.000 | 0.048 | 0.131 | 0.623 | 0.943 | 0.994 |
| Prostate | 0.74 (0.62-0.88) | 7.44*10-4 | 0.998 | 0.002 | 0.007 | 0.069 | 0.427 | 0.882 |
| Ovarian | 0.73 (0.61-0.87) | 5.68*10-4 | 0.979 | 0.002 | 0.005 | 0.054 | 0.367 | 0.853 |
| OSCC | 0.67 (0.51-0.88) | 3.99*10-3 | 0.800 | 0.015 | 0.043 | 0.331 | 0.833 | 0.980 |
| Asians | 0.86 (0.79-0.94) | 7.59*10-4 | 1.000 | 0.002 | 0.007 | 0.070 | 0.431 | 0.884 |
| Chinese | 0.84 (0.77-0.93) | 4.59*10-4 | 1.000 | 0.001 | 0.004 | 0.043 | 0.314 | 0.821 |
| HB | 0.88 (0.80-0.98) | 0.015 | 1.000 | 0.043 | 0.118 | 0.596 | 0.937 | 0.993 |
| Recessive (DD vs. ID/II) | ||||||||
| All | 0.81 (0.71-0.91) | 3.22*10-4 | 1.000 | 0.001 | 0.003 | 0.031 | 0.243 | 0.763 |
| NPC | 0.73 (0.63-0.85) | 3.26*10-5 | 0.841 | 0.000 | 0.000 | 0.004 | 0.037 | 0.279 |
| Prostate | 0.77 (0.65-0.92) | 3.78*10-3 | 0.999 | 0.011 | 0.033 | 0.272 | 0.791 | 0.974 |
| Ovarian | 0.68 (0.52-0.89) | 4.62*10-3 | 0.976 | 0.014 | 0.041 | 0.319 | 0.826 | 0.979 |
| OSCC | 0.63 (0.49-0.81) | 2.37*10-4 | 0.356 | 0.002 | 0.006 | 0.062 | 0.399 | 0.869 |
| Asians | 0.75 (0.65-0.86) | 6.02*10-5 | 1.000 | 0.000 | 0.001 | 0.006 | 0.057 | 0.376 |
| Chinese | 0.77 (0.67-0.88) | 1.44*10-4 | 1.000 | 0.000 | 0.001 | 0.014 | 0.126 | 0.591 |
| HB | 0.76 (0.65-0.89) | 5.23*10-4 | 1.000 | 0.002 | 0.005 | 0.049 | 0.343 | 0.840 |
| QS ≤9 | 0.73 (0.60-0.88) | 1.23*10-3 | 1.000 | 0.004 | 0.011 | 0.109 | 0.551 | 0.925 |
| Dominant (ID/DD vs. II) | ||||||||
| All | 0.86 (0.78-0.95) | 2.68*10-4 | 1.000 | 0.008 | 0.024 | 0.210 | 0.728 | 0.964 |
| NPC | 0.79 (0.69-0.90) | 2.94*10-4 | 0.997 | 0.001 | 0.003 | 0.028 | 0.227 | 0.747 |
| Prostate | 0.69 (0.59-0.81) | 8.36*10-6 | 0.796 | 0.000 | 0.000 | 0.001 | 0.010 | 0.095 |
| Ovarian | 0.67 (0.56-0.79) | 3.45*10-6 | 0.531 | 0.000 | 0.000 | 0.001 | 0.006 | 0.061 |
| OSCC | 0.60 (0.46-0.77) | 9.87*10-5 | 0.186 | 0.002 | 0.005 | 0.050 | 0.347 | 0.842 |
| Asians | 0.80 (0.72-0.89) | 9.05*10-5 | 1.000 | 0.000 | 0.001 | 0.009 | 0.083 | 0.475 |
| Chinese | 0.80 (0.71-0.89) | 9.39*10-5 | 1.000 | 0.000 | 0.001 | 0.009 | 0.086 | 0.484 |
| HB | 0.84 (0.74-0.94) | 2.29*10-3 | 1.000 | 0.007 | 0.020 | 0.185 | 0.696 | 0.958 |
| QS ≤9 | 0.83 (0.71-0.96) | 0.013 | 1.000 | 0.038 | 0.105 | 0.563 | 0.929 | 0.992 |
| Allele (D vs. I) | ||||||||
| All | 0.88 (0.81-0.95) | 8.86*10-4 | 1.000 | 0.003 | 0.008 | 0.081 | 0.469 | 0.899 |
| NPC | 0.81 (0.74-0.89) | 9.60*10-6 | 1.000 | 0.000 | 0.000 | 0.001 | 0.009 | 0.088 |
| Prostate | 0.79 (0.72-0.87) | 1.03*10-6 | 1.000 | 0.000 | 0.000 | 0.000 | 0.001 | 0.010 |
| Ovarian | 0.75 (0.65-0.86) | 3.47*10-5 | 1.000 | 0.000 | 0.000 | 0.003 | 0.033 | 0.257 |
| OSCC | 0.70 (0.60-0.82) | 1.11*10-5 | 0.809 | 0.000 | 0.000 | 0.001 | 0.014 | 0.121 |
| Asians | 0.83 (0.76-0.91) | 4.78*10-5 | 1.000 | 0.000 | 0.000 | 0.005 | 0.046 | 0.323 |
| Chinese | 0.84 (0.76-0.91) | 9.24*10-5 | 1.000 | 0.000 | 0.001 | 0.009 | 0.085 | 0.480 |
| HB | 0.85 (0.77-0.94) | 9.63*10-4 | 1.000 | 0.003 | 0.009 | 0.087 | 0.490 | 0.906 |
| QS ≤9 | 0.84 (0.75-0.95) | 4.84*10-3 | 1.000 | 0.014 | 0.042 | 0.324 | 0.829 | 0.980 |
CI, confidence interval; OR, odds ratio; NPC, Nasopharyngeal carcinoma; OSCC, oral squamous cell carcinoma; HB, Hospital based; QS, quality score.
a Chi-square test was adopted to calculate the genotype frequency distributions.
b Statistical power was calculated using the number of observations in the subgroup and the OR and P values in this table.