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. 2016 Dec 25;8(6):9868–9884. doi: 10.18632/oncotarget.14196

Figure 10. Targeting CSC propagation with palbociclib, a CDK4/6 inhibitor, in lung, ovarian and breast cancers.

Figure 10

Parental A549 and SKOV3 cells were seeded in low-attachment plates and treated with the indicated concentrations of PD-0332991 (palbociclib) for five days. Then, the number of 3D-spheroids formed was quantitated. Note that palbociclib treatment very effectively inhibited 3D-sphere formation in A549 (panel A) and SKOV3 cells (panel B), with an IC-50 < 100 nM. Virtually identical results were also obtained with MCF7 cells (panel C). Data represent three independent experiments. Results are shown as the mean ± SEM, t-test, two-tailed test. Asterisk (*) depicts significant change, p<0.05. *p < 0.05, **p < 0.005, ***p < 0.0001.