Table 2. Proteomics: Key Molecules Up-regulated in hTERT-GFP(+) SKOV3 Ovarian Cancer Cells Isolated by FACS.
| Symbol | Description | Fold-Upregulation(GPF(+)/GFP(-)) |
|---|---|---|
| Mitochondrial-related proteins | ||
| MRPL15 | Mitochondrial ribosomal protein L15 | 11.65 |
| SLC25A10 | Mitochondrial dicarboxylate carrier | 10.11 |
| DUT | Deoxyuridine 5′-triphosphate nucleotidohydrolase, mitochondrial | 9.48 |
| VDAC2 | Voltage-dependent anion channel 2 | 7.23 |
| COX5A | Cytochrome c oxidase subunit 5A, mitochondrial | 7.08 |
| MT-CO2 | Cytochrome c oxidase subunit 2, mt-DNA encoded | 6.08 |
| PRKDC | DNA-dependent protein kinase catalytic subunit | 5.90 |
| SHMT2 | Serine hydroxymethyltransferase, mitochondrial | 5.71 |
| HSPD1 | 60 kDa heat shock protein, mitochondrial | 5.44 |
| FECH | Ferrochelatase, mitochondrial | 5.23 |
| ATP5B | ATP synthase subunit beta | 4.54 |
| SOD2 | Superoxide dismutase 2 | 4.27 |
| YARS2 | Tyrosine--tRNA ligase, mitochondrial | 4.18 |
| DLST | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial | 4.10 |
| TUFM | Elongation factor Tu, mitochondrial | 4.00 |
| ALDH1B1 | Aldehyde dehydrogenase X, mitochondrial | 3.27 |
| PMPCA | Mitochondrial-processing peptidase subunit alpha | 3.25 |
| CS | Citrate synthase | 3.25 |
| MTCH2 | Mitochondrial carrier homolog 2 | 3.10 |
| ECI1 | Enoyl-CoA delta isomerase 1, mitochondrial | 2.41 |
| AK2 | Adenylate kinase 2, mitochondrial | 2.41 |
| SDHA | Succinate dehydrogenase flavoprotein subunit, mitochondrial | 2.39 |
| HSPA9 | Stress-70 protein, mitochondrial | 2.38 |
| ACO2 | Aconitase 2, mitochondrial | 1.82 |
| IDH3A | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 1.52 |
| Glycolysis and PPP | ||
| LDHAL6B | L-lactate dehydrogenase A-like 6B | 8.51 |
| PGK2 | Phosphoglycerate kinase 2 | 6.91 |
| ENO3 | Enolase | 4.16 |
| PKLR | Pyruvate kinase isozymes R/L | 3.71 |
| ENO2 | Enolase | 3.56 |
| HK1 | Hexokinase-1 | 3.25 |
| LDHB | L-lactate dehydrogenase B | 3.08 |
| Glycogen-related | ||
| PYGB | Glycogen phosphorylase, brain form | 1.63 |
Proteomic analysis of hTERT-GFP SKOV3 cells. Data are derived from the analysis of FACS sorted cell populations. The fold-increase of certain key molecules in GFP(+) cells is shown, relative to GFP(-) cells. Note that several protein targets related to mitochondrial metabolism and glycolysis are increased in GFP(+) cells.