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. 2016 Nov 22;8(3):3854–3869. doi: 10.18632/oncotarget.12924

Figure 2. A. Schematic representation of the NDRG1 promoter.

Figure 2

B. and C. MYCN and LSD1 binding to NDRG1 chromatin. Cell treatments are indicated at the bottom of the figure. qPCR was performed with primers for NDRG1 TSS, and -10kb. D. and E. Histone modifications at NDRG1 chromatin; ChIPs were carried out using the indicated antibodies and analyzed with primers encompassing the TSS region and -10kb from TSS. Values from three independent ChIP assays are presented along with standard deviations, n = 3. Changes in % input are shown normalized over IgG controls and are all statistically significant (P < 0,05; Student t test).