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. 2016 Nov 10;8(3):4051–4061. doi: 10.18632/oncotarget.13266

Figure 4. Effect of DDIT3, NAG-1, PERK on the induction of apoptosis by K8 in 8401.

Figure 4

(A, D) 8401 cells were transfected with various concentrations of DDIT3 or NAG-1 siRNA (10, 20 nM ) and treated with K8 for 24 hrs. (B, E) Western blot analysis were performed for DDIT3, NAG-1 and cleaved capase3. (C) K8 induced NAG-1 expression in 8401 and G2T cell lines. (F) 8401 cells were first treated with 10 nM PERK inhibitor GSK2606414 for 24 hrs and then treated with K8 in a dose-dependent manner. (G) Western blot analysis was performed for PERK and DDIT3. Level of statistical significance: *p < 0.05, **p < 0.01.