Figure 2. MPH selectively suppresses the growth of HR-deficient xenografts and sensitizes HR-proficient xenografts to the DNA damaging agent TMZ in nude mice.

The mice bearing subcutaneous xenografts were orally given MPH once every other day and/or TMZ once each day on Monday to Friday every week, either alone or in combination. Relative tumor volume (RTV) and body weight were separately plotted over the treatment time. The xenografts or the mice tails if the xenografts disappeared in the corresponding mice were separately taken for photographing at the end of treatments. (A–C) the effect of MPH alone on BRCA2-deficient V-C8 (A), BRCA2-proficient V79 (B) and BRCA1-deficient MDA-MB-436 (C) xenografts. (D) the effect of MPH and TMZ, alone or in combination, on HR-proficient SW620 xenografts.