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. 2016 Dec 9;8(3):4277–4288. doi: 10.18632/oncotarget.13834

Figure 1. Feedback induction of HER3 phosphorylation after 24h EGFR inhibition with cetuximab.

Figure 1

(A) LIM1215 and HCA7 cells were treated for 24h with cetuximab (50 μg/mL) or control-treated with DMSO and phosphorylation of a set of RTKs was assessed with RTK arrays as described in the Materials and Methods section. (B) RTK arrays quantification. (C) LIM1215 and HCA7 cells were treated with cetuximab (50 μg/mL) for different time points. Protein levels were detected by western blotting as described in the Materials and Methods section. (D) Western blotting quantification of P-HER3/HER3.