Skip to main content
. 2016 Dec 10;8(3):4449–4459. doi: 10.18632/oncotarget.13879

Figure 5. A schematic model of Akt-mediated negative regulation of FOXOs/GABARAPL1 in CaP progress and metastasis.

Figure 5

Activated Akt directly phosphorylates FOXOs and leads to their inactivation, which subsequently inhibits the expression of their target gene GABARAPL1 and results in enhanced CaP invasion and metastasis.