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. 2016 Nov 7;8(3):4484–4500. doi: 10.18632/oncotarget.13152

Figure 8. Summary of ARHGEF2 transactivation and regulation of RAS mediated phenotypes via ARHGEF2-regulating TFs.

Figure 8

A. The transactivation of the ARHGEF2 promoter by ELK1, ETS1, SP1, and SP3 activates RAS mediated phenotypes (+), whereas repression of ARHGEF2 by RREB1 inhibits RAS mediated phenotypes (−). B. Activated ARHGEF2 expression (green arrows) rescued RAS mediated phenotypes (+) observed with knockdown of RREB1, ELK1, or SP1 (left); however, knockdown of RREB1, ETS1, or SP3 (right) failed to activate ARHGEF2 expression (red arrows) or rescue RAS mediated phenotypes (−). Shaded TFs represent knocked down genes. C. Enforced expression of ARHGEF2 rescued RAS mediated phenotypes (+) observed with knockdown of SP3 (left) but could not rescue (−) phenotypes associated with knockdown of ELK1, ETS1, or SP1 (right). Shaded TFs represent knocked down genes.