Table 2. Enriched KEGG signalling pathways among up- and down-regulated protein-coding genes.
| Enriched KEGG signalling pathways | Genes in pathway (n) | P-value* |
|---|---|---|
| Up-regulated pathways | ||
| Pathways in cancer | 23 | 1.7 ×10−6 |
| Spliceosome | 13 | 1.4 ×10−5 |
| Basal cell carcinoma | 9 | 1.4 ×10−5 |
| mRNA surveillance pathway | 10 | 4.6 ×10−5 |
| Wnt signalling pathway | 12 | 0.0003 |
| Notch signalling pathway | 6 | 0.0036 |
| Small cell lung cancer | 7 | 0.0088 |
| Prostate cancer | 7 | 0.0088 |
| Glioma | 6 | 0.0088 |
| Focal adhesion | 11 | 0.0088 |
| Down-regulated pathways | ||
| Porphyrin and chlorophyll metabolism | 5 | 0.0009 |
| Renin-angiotensin system | 3 | 0.0072 |
| Neuroactive ligand-receptor interaction | 8 | 0.0115 |
| Cytokine-cytokine receptor interaction | 8 | 0.0115 |
| Pathogenic Escherichia coli infection | 4 | 0.0115 |
| Alzheimer's disease | 6 | 0.0152 |
| Calcium signalling pathway | 6 | 0.0155 |
| SNARE interactions in vesicular transport | 3 | 0.0155 |
| Metabolic pathways | 18 | 0.0043 |
| Oxidative phosphorylation | 5 | 0.0168 |
*
P-value indicates the significance of the enrichment (p-value < 0.05)