Table 2. Meta-analysis of IL-23R polymorphisms in UC.
| Polymorphisms | Population | NO. of studies | Sample size | Test of association | Test of heterogeneity | Egger's test (P) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case | Control | OR (95% CI) | Z | P | Model | χ2 | P | I2(%) | ||||
| rs11209026 | Overall | 25 | 8243 | 12899 | 0.665 (0.604~0.733) | 8.25 | <0.001 | F | 17.15 | 0.876 | 0.0 | 0.187 |
| A versus G allele | Caucasian | 23 | 8141 | 12799 | 0.662 (0.600~0.729) | 8.30 | <0.001 | F | 16.15 | 0.849 | 0.0 | 0.092 |
| Asian | 2 | 102 | 100 | 1.004 (0.452~2.232) | 0.01 | 0.992 | F | 0.03 | 0.864 | 0.0 | NA | |
| rs7517847 | Overall | 12 | 3589 | 5536 | 0.818 (0.768~0.871) | 6.31 | <0.001 | F | 5.78 | 0.887 | 0.0 | 0.535 |
| G versus T allele | Caucasian | 11 | 3319 | 5268 | 0.817 (0.766~0.871) | 6.14 | <0.001 | F | 5.76 | 0.835 | 0.0 | 0.570 |
| Asian | 1 | 270 | 268 | 0.833 (0.652~1.063) | 1.47 | 0.142 | NA | NA | NA | NA | NA | |
| rs1004819 | Overall | 11 | 4555 | 6994 | 1.196 (1.129~1.267) | 6.09 | <0.001 | F | 6.98 | 0.727 | 0.0 | 0.264 |
| T versus C allele | Caucasian | 9 | 3677 | 6131 | 1.208 (1.133~1.287) | 5.80 | <0.001 | F | 6.15 | 0.631 | 0.0 | 0.216 |
| Asian | 2 | 878 | 863 | 1.146 (1.002~1.311) | 1.98 | 0.047 | F | 0.35 | 0.553 | 0.0 | NA | |
| rs10889677 | Overall | 10 | 3948 | 5998 | 1.201 (1.127~1.280) | 5.64 | <0.001 | F | 7.24 | 0.612 | 0.0 | 0.461 |
| A versus C allele | Caucasian | 8 | 3025 | 5134 | 1.217 (1.134~1.306) | 5.47 | <0.001 | F | 5.99 | 0.541 | 0.0 | 0.539 |
| Asian | 2 | 923 | 864 | 1.132 (0.976~1.313) | 1.64 | 0.101 | F | 0.49 | 0.483 | 0.0 | NA | |
| rs2201841 | Overall | 9 | 3265 | 4638 | 1.163 (1.083~1.249) | 4.15 | <0.001 | F | 6.09 | 0.638 | 0.0 | 0.090 |
| C versus T allele | Caucasian | 7 | 2356 | 3783 | 1.175 (1.083~1.274) | 3.87 | <0.001 | F | 5.08 | 0.533 | 0.0 | 0.026 |
| 7a | NA | NA | 1.176 (1.084~1.275) | 3.92 | <0.001 | F | NA | NA | NA | NA | ||
| Asian | 2 | 909 | 855 | 1.126 (0.971~1.307) | 1.57 | 0.117 | F | 0.76 | 0.382 | 0.0 | NA | |
| rs11209032 | Overall | 9 | 4073 | 5752 | 1.127 (1.060~1.197) | 3.85 | <0.001 | F | 5.27 | 0.729 | 0.0 | 0.249 |
| A versus G allele | Caucasian | 6 | 3041 | 4762 | 1.116 (1.041~1.197) | 3.10 | 0.002 | F | 4.82 | 0.438 | 0.0 | 0.044 |
| 6a | NA | NA | 1.120 (1.044~1.201) | 3.12 | 0.002 | F | NA | NA | NA | NA | ||
| Asian | 3 | 1032 | 990 | 1.160 (1.025~1.312) | 2.35 | 0.019 | F | 0.16 | 0.922 | 0.0 | 0.312 | |
| rs1495965 | Overall | 8 | 3415 | 5473 | 1.073 (1.008~1.141) | 2.22 | 0.026 | F | 7.19 | 0.409 | 2.6 | 0.392 |
| G versus A allele | Caucasian | 6 | 2492 | 4609 | 1.072 (0.999~1.149) | 1.94 | 0.053 | F | 7.17 | 0.208 | 30.3 | 0.482 |
| Asian | 2 | 923 | 864 | 1.076 (0.944~1.227) | 1.09 | 0.274 | F | 0.02 | 0.892 | 0.0 | NA | |
| rs1343151 | Overall | 8 | 3241 | 4989 | 0.900 (0.836~0.969) | 2.80 | 0.005 | F | 10.57 | 0.158 | 33.8 | 0.213 |
| T versus C allele | Caucasian | 6 | 2836 | 4587 | 0.916 (0.812~1.032) | 1.45 | 0.148 | R | 10.49 | 0.063 | 52.3 | 0.142 |
| Asian | 2 | 405 | 402 | 0.992 (0.513~1.922) | 0.02 | 0.982 | F | 0.0 | 1.000 | 0.0 | NA | |
| rs10489629 | Overall | 6 | 3029 | 4777 | 0.944 (0.837~1.065) | 0.93 | 0.350 | R | 14.14 | 0.015 | 64.9 | 0.259 |
| G versus A allele | Caucasian | 5 | 2759 | 4509 | 0.951 (0.829~1.090) | 0.72 | 0.470 | R | 14.14 | 0.007 | 71.7 | 0.179 |
| Asian | 1 | 270 | 268 | 0.914 (0.692~1.206) | 0.64 | 0.525 | NA | NA | NA | NA | NA | |
| rs11465804 | Overall | 5 | 2530 | 4428 | 0.760 (0.639~0.904) | 3.10 | 0.002 | F | 2.39 | 0.664 | 0.0 | 0.747 |
| G versus T allele | Caucasian | 5 | 2530 | 4428 | 0.760 (0.639~0.904) | 3.10 | 0.002 | F | 2.39 | 0.664 | 0.0 | 0.747 |
Abbreviations: UC: Ulcerative Colitis, F: fixed effects model, R: random effects model, NA: not available.
* Adjusted using the “trim and fill” method.