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. 2016 Dec 3;8(3):5048–5056. doi: 10.18632/oncotarget.13790

Figure 3. Knockdown FOXD3 increased human colon cancer cell metastasis.

Figure 3

A and B. HCT116 and Caco-2 cells were transduced with FOXD3 siRNA or siControl for 48h and the transwell invasion experiments and quantitative assay were performed. The cells were allowed to migrate for 24 h at 37°C. Data are expressed as mean ± SD (n = 3). (Scale bar, 100μm; original magnification, ×10).*p<0.05, **p<0.01, siControl versus siFOXD3. C and D. Cells were treated with scrambled siRNA (control) or FOXD3 siRNA and then collected for Western Blot analysis. Cells were lysed 72 h post-infection with shRNAs and analyzed by immunoblotting with the antibodies against N-cadherin, E-cadherin and FOXD3.