Figure 5. MiR-433-3p inhibits glioma growth in nude mice.
A. The U87 xenograft experiments were performed to confirm the effects of miR-433-3p on tumor growth in vivo. The tumor volume was measured with a caliper every 3 days using the formula, volume = length × width2/2. B. Photography of the U87 xenograft tumor was shown at the end of a 21-day observation period. C. The expression levels of miR-433-3p in tumor treated with miR-433-3p mimics were analyzed by quantitative RT-PCR. D. Immunohistochemical analysis was used to detect the expression of CREB protein in xenograft tumor after treatment with miR-433-3p mimics. Scale bars, 50μm. All data are shown as mean ± SD.*P < 0.05 versus Scramble.