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. 2016 Dec 10;8(3):5092–5110. doi: 10.18632/oncotarget.13867

Figure 9. Inhibition of Akt and MAPKs hinders the CUG2-induced EMT.

Figure 9

A549-CUG2 and BEAS-CUG2 cells were treated with wortmannin (Wort), PD98059 (PD), SP600125 (SP), or SB203580 (SB). A wound healing assay was performed for cell migration. The wound closure areas were monitored by phase-contrast microscopy at a magnification of 100×. The assay was repeated twice. Cell invasion assay was performed using 48-well Boyden chambers. The chamber was assembled using polycarbonate filters coated with Matrigel. Scale bar indicates 100 μm. The assay was repeated twice. Each assay was performed in triplicate. Error bar indicates SD. All ***; p <0.001, except **; p<0.01 in BEAS-CUG2 cells treated with PD.