Table 5. Circuits which are most significantly associated to survival than their constituent genes.
| Circuit | Circuit Status | Adjusted p-value | Gene | GeneStatus | Adjusted p-value | General functional category | Function Status | Adjusted p-value |
|---|---|---|---|---|---|---|---|---|
| Cell cycle: CDC45 MCM7 MCM6 MCM5 MCM4 MCM3 MCM2 | UP | 6.08E-11 | CDC7 | UP | 1.68E-07 | DNA replication | UP | 5.94E-08 |
| Cell cycle: ORC3 ORC5 ORC4 ORC2 ORC1 ORC6 MCM7 MCM6 MCM5 MCM4 MCM3 MCM2 | UP | 1.26E-09 | CDC7 | UP | 1.68E-07 | DNA replication | UP | 5.94E-08 |
| Glucagon signaling pathway: G6PC | DOWN | 6.57E-06 | PPARGC1A | DOWN | 1.97E-05 | Gluconeogenesis | DOWN | 8.96E-06 |
| Glucagon signaling pathway: PCK1 | DOWN | 4.31E-07 | PPARGC1A | DOWN | 1.97E-05 | Gluconeogenesis | DOWN | 8.96E-06 |
| PPAR signaling pathway: PCK1 | DOWN | 3.75E-05 | PCK1 | DOWN | 6.39E-05 | Gluconeogenesis | DOWN | 8.96E-06 |
| PPAR signaling pathway: LPL | DOWN | 0.00095506 | LPL | DOWN | 0.00509595 | Lipid metabolism | DOWN | 1.59E-05 |
| PPAR signaling pathway: CYP7A1 | UP | 0.00209578 | RXRA | DOWN | 0.00577708 | Lipid metabolism | DOWN | 1.59E-05 |
| Leukocyte transendothelial migration: CDH5 | DOWN | 4.81E-05 | CDH5 | DOWN | 6.14E-05 | Cell adhesion | DOWN | 4.46E-05 |
| Adherens junction: CTNNA1 CTNNB1 | DOWN | 3.91E-05 | CTNNA1 | DOWN | 0.00016432 | Cell adhesion | DOWN | 4.46E-05 |
| PPAR signaling pathway: CD36 | DOWN | 5.46E-05 | CD36 | DOWN | 0.00030595 | Cell adhesion | DOWN | 4.46E-05 |
| Proteoglycans in cancer: ITGAV* | DOWN | 4.81E-05 | ITGAV | DOWN | 0.0006759 | Cell adhesion | DOWN | 4.46E-05 |
| Leukocyte transendothelial migration: PECAM1 | DOWN | 0.00063309 | PECAM1 | DOWN | 0.0009573 | Cell adhesion | DOWN | 4.46E-05 |
| Adherens junction: CDH1* | DOWN | 0.00637905 | CDH1 | DOWN | 0.0078199 | Cell adhesion | DOWN | 4.46E-05 |
| AMPK signaling pathway: CCNA2 | UP | 1.04E-12 | STRADA | UP | 1.34E-07 | Cell division | DOWN | 0.00152171 |
| Tight junction: PARD6A MPP5 | DOWN | 1.45E-05 | CDC42 | DOWN | 0.00011452 | Cell division | DOWN | 0.00152171 |
The circuits are defined as the pathway to which it belongs to and the final effector node that triggers the function. The status for circuits, genes and functions are UP or DOWN depending on the respective increase or decrease of their activities when the cancer is compared to the normal tissue. The gene column contains the gene with the best association to survival (lower adjusted p-value) among all the genes in the corresponding circuit.