Table 3. Univariate analysis of factors associated with overall survival.
| Variable | HR | 95% CI | P-value |
|---|---|---|---|
| Age at diagnosis (y>50/y≤50) | 1.49 | 0.79-2.82 | 0.218 |
| Menopausal status (Pre/Post) | 0.66 | 0.35-1.23 | 0.192 |
| Tumor size (>2cm/≤2cm) | 0.55 | 0.27-1.14 | 0.109 |
| Nodal status (N3+N2/N1+N0) | 3.28 | 1.54-6.95 | 0.002 |
| ER status (+/−) | 0.67 | 0.34-1.34 | 0.260 |
| PR status (+/−) | 0.64 | 0.34-1.20 | 0.163 |
| TNM stages (IV/III+II+I) | 4.64 | 2.34-9.20 | 0.000 |
| Intratumoral TILs (≥10%/<10%) | 0.35 | 0.11-1.13 | 0.078 |
| Stromal TILs (≥10%/<10%) | 0.52 | 0.27-0.99 | 0.045 |
| Intratumoral FXOP3+ Tregs (high/low) | 1.09 | 0.58-2.05 | 0.783 |
| Stromal FXOP3+ Tregs (high/low) | 1.95 | 1.01-3.75 | 0.045 |
| Intratumoral CD68+ Mφ(high/low) | 1.83 | 0.96-3.49 | 0.065 |
| Stromal CD68+ Mφ(high/low) | 2.24 | 1.16-4.34 | 0.017 |
| Intratumoral IL17+ Th17 (high/low) | 1.26 | 0.65-2.44 | 0.494 |
| Stromal IL17+ Th17 (high/low) | 1.23 | 0.65-2.33 | 0.525 |
| FOXP3+ cancer cells (high/low) | 0.49 | 0.25-0.99 | 0.048 |
Abbreviation: HR, hazard ratio; CI, confidence interval; ER, estrogen receptor; PR, progestrone receptor; TILs, tumor-infiltrating lymphocytes; Tregs, regulatory T cells; Mφ, macrophage; Th17, T helper cell 17;