Table 4. Multivariate analysis of factors associated with overall survival.
| Variable | HR | 95% CI | P-value |
|---|---|---|---|
| Age at diagnosis (y>50/y≤50) | 0.03 | 0.00-0.56 | 0.018 |
| Menopausal status (Pre/Post) | 0.02 | 0.00-0.29 | 0.005 |
| Tumor size (>2cm/≤2cm) | 0.15 | 0.05-0.47 | 0.001 |
| Nodal status (N3+N2/N1+N0) | 6.39 | 1.90-21.5 | 0.003 |
| ER status (+/−) | 0.65 | 0.24-1.75 | 0.390 |
| PR status (+/−) | 1.50 | 0.53-4.21 | 0.442 |
| TNM stages (IV/III+II+I) | 5.36 | 1.33-21.5 | 0.018 |
| Intratumoral TILs (≥10%/<10%) | 0.32 | 0.06-1.56 | 0.157 |
| Stromal TILs (≥10%/<10%) | 1.12 | 0.41-3.08 | 0.831 |
| Stromal FXOP3+ Tregs (high/low) | 1.34 | 0.53-3.38 | 0.534 |
| Intratumoral CD68+ Mφ(high/low) | 2.70 | 1.00-7.31 | 0.050 |
| Stromal CD68+ Mφ(high/low) | 1.85 | 0.72-4.73 | 0.200 |
| FOXP3+ cancer cells (high/low) | 0.29 | 0.09-0.91 | 0.034 |
Abbreviation: HR, hazard ratio; CI, confidence interval; ER, estrogen receptor; PR, progestrone receptor; TILs, tumor-infiltrating lymphocytes; Tregs, regulatory T cells; Mφ, macrophage;