Figure 1. The imbalanced miRNAs axis consisted of upregulated pair of miR-31/miR-203 and down regulated pair of hsa-miR-99a/miR-125b plays a critical role in controlling proliferation and differentiation in psoriatic keratinocytes.

This imbalance between miR-31/miR-203 and hsa-miR-99a/miR-125b is like “Yin” and “Yang” in Chinese medicine, which means these two pairs of miRNAs are opposite or contrary in expression, but they are actually complementary, interconnected, and interdependent in the development of psoriasis pathogenesis. Abbreviations: ppp6c = protein phosphatase 6; FIH-1 = factor-inhibiting hypoxia-inducible factor 1; IGF-1R = insulin-like growth factor 1 receptor; FGFR2 = fibroblast growth factor receptor 2; p63 = protein 63; SOCS-3 = suppressor of cytokine signaling 3; PI3K = Phosphatidylinositol-4,5-bisphosphate 3-kinase; JAK = Janus Kinase; RAN = Ras-related Nuclear protein.