. 2016 Oct 8;8(3):5498–5507. doi: 10.18632/oncotarget.12534

Table 1. The functions and related molecules of four key miRNAs identified in psoriasis skin.

MiRNAs	Region, Tissues or Cells Expressed	Target Gene	Expression in Psoriasis	Roles of miRNAs in			Other Information	References
MiRNAs	Region, Tissues or Cells Expressed	Target Gene	Expression in Psoriasis	Proliferation	Differentiation	Inflammation	Other Information	References
MiR-31	Psoriatic keratinocytes	ppp6c, STK40, FIH-1,EMP-1	Up	↑	↑	↑	MiR-31 can be induced by TGF-β1,IL-6 and IL-17A	[10–12, 16]
MiR-203	Keratinocytes in Psoriatic lesions; Normal human keratinocytes stimulated by combinations of pro-inflammatory cytokines	SOCS-3,p63, LASP1,RAPH1,RAN,TNFα, IL-24	Up		↑	↑	Skin-specific miRNA; Exclusively expressed in psoriatic keratinocytes	[6, 44, 50]
Hsa-miR-99a	Normal skin and psoriatic skin	IGF-1R	Down	↓	↑	-	One of the strongest down-regulated miRNAs in psoriatic skin	[9, 48]
MiR-125b	Fibroblasts, keratinocytes, and melanocytes	FGFR2, p63, Notch 1,TNFα	Down	↓	↑	↓	One of the most downregulated miRNAs in psoriasis skin.	[6, 15, 49]

ppp6c=protein phosphatase 6; STK40=serine/threonine kinase 40; FIH-1=factor-inhibiting hypoxiainducible factor 1; EMP-1=epithelial membrane protein 1; IGF-1R=insulin-like growth factor 1 receptor; FGFR2=fibroblast growth factor receptor 2; p63=protein 63; TNF=tumor necrosis factor; SOCS-3=suppressor of cytokine signaling 3; LASP1=LIM and SH3 domain protein 1; RAPH1=Ras-associated and pleckstrin homology domains-containing protein 1;RAN=Ras-related Nuclear protein; TGF-β=Transforming growth factor beta. “↑”=promote; “↓”=inhibit.