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EWS-FLI1 binds the promoters of target genes, which increases IGF1 expression, and decreases IGFBP3 expression. IGF1 interacts with IGF1R, and activates the IGF1 pathway, which mediates cellular proliferation, survival, etc. Treatment with IGF1R inhibitors and antibodies suppresses activation of the IGF1 pathway. IGF1, insulin-like growth factor 1; IGFBP3, insulin-like growth factor binding protein 3.
