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EWS-FLI1 interacts with PARP1, driving PARP1 expression. PARP1 promotes the transcriptional activation by EWS-FLI1. Treatment of ES with the PARP1 inhibitor olaparib could both disrupt the interaction between EWS-FLI1 and PARP1, and impair DNA repair, which represses tumorigenesis. PARP1, Poly(ADP-ribose) polymerase 1.
