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. 2016 Nov 25;8(3):5603–5618. doi: 10.18632/oncotarget.13629

Figure 3. VEGF-C increases Slug expression, cell migration, invasion and stemness through YAP1.

Figure 3

a. (Upper panel) Western blot analysis of Slug and YAP1 in indicated cells. Tubulin was used as a loading control. (Lower panel) QRT-PCR analysis of VEGF-C expression in indicated cells. b. A transwell assay demonstrated the migration and invasion abilities of indicated cells. c and d. QRT-PCR analysis of SOX2 and OCT4 mRNA expression in indicated cells. e. ALDH activity of indicated cells was determined by flow cytometry. f-h. The Oncomine database was used to analyze the correlation of VEGF-C, YAP1 and Slug with survival rate in skin cancer patients. The results are shown as the mean ± SD of three independent experiments, each performed in triplicate. *P < 0.05, **P < 0.001, ***P < 0.0001 (Student's t test).