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Characteristics of GPR56 and GPR126
| GPR56 | GPR126 | |
|---|---|---|
| Primary System of Action | CNS | PNS |
| Responsible Glial Cell | Oligodendrocytes | Schwann cells |
| Area of Regulation | Proliferation | Radial sorting and myelination |
| Endogneous Ligands | Collagen III (Transglutaminase 2) (in cancer) |
Laminin-211 Collagen IV PrPc |
| Downstream Signaling | RhoA | cAMP |
| Associated Human Disease | Bilateral Frontoparietal Polymicrogyria | Arthrogryposis Multiplex Congenita |
