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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Leuk Res. 2017 Jan 12;55:23–32. doi: 10.1016/j.leukres.2017.01.007

Figure 7. Dexamethasone and BTdCPU promote apoptosis in MM through the modulation of protein translation.

Figure 7

Multiple Myeloma cells express high levels of eIF2α. Both BTdCPU and dexamethasone treatment result in phosphorylation of eIF2α (solid arrows) and translational alterations including downregulation of translational machinery components and upregulation of ATF4, promoting apoptosis. Dex may also promote apoptosis through additional translational pathways, including mTOR (dashed arrow).