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. Author manuscript; available in PMC: 2017 Sep 15.
Published in final edited form as: Cancer Res. 2017 Mar 2;77(6):1283–1295. doi: 10.1158/0008-5472.CAN-15-3545

Figure 2. Bone pain and SN activation in JJN3-injected mice.

Figure 2

A. Mechanical allodynia. * p<0.05, ** p<0.01 vs sham mice (mean ± SE, n=16). Arrow indicates a single intraperitoneal injection of Baf A1 (25µg/kg) or vehicle (0.1% DMSO in PBS).

B. Thermal hyperalgesia. * p<0.05 vs sham mice (mean ± SE, n=16). Arrow indicates a single intraperitoneal injection of Baf A1 (25µg/kg) or vehicle (0.1% DMSO in PBS).

C. Sprouting of CGRP+ SNs in tibiae.

D. Quantitative data of C. * p<0.05 vs sham mice (mean ± SE, n=16).

E. Acidification of bone marrow shown by acridine orange accumulation.

F. Time-course of inhibition of mechanical allodynia, following a single intraperitoneal injection of Baf A1 (25µg/kg) or vehicle (0.1% DMSO in PBS) (arrow in A and B). * p<0.05 vs vehicle-treated JJN3-injected mice (mean ± SE, n=8).

G. Thermal hyperalgesia, following a single intraperitoneal injection of Baf A1 (25µg/kg) or vehicle (0.1% DMSO in PBS) (arrow in A and B). * p<0.05 vs vehicle-treated JJN3-injected mice (mean ± SE, n=8).

H. Excitation of sensory nerves determined by pERK1/2 and pCREB expression in DRG in sham and JJN3-injected mice.